Oroxylin A
Request a quote| Catalog Number | ACM480115 |
| CAS | 480-11-5 |
| Structure | ![{[CurrentData.Name]}](https://resource.alfa-chemistry.com/structure/480-11-5.gif) |
| Description | Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells . Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability . Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation .In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well . |
| Molecular Weight | 284.26 |
| Molecular Formula | C16H12O5 |
| Canonical SMILES | O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13 |
| Purity | 99.87% |
| Appearance | Solid |
| Storage | Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month. |
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