Eurycomalactone
Request a quote| Catalog Number | ACM23062240-1 |
| CAS | 23062-24-0 |
| Structure | ![{[CurrentData.Name]}](https://resource.alfa-chemistry.com/structure/23062-24-0.gif) |
| Description | Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent NF-κB inhibitor with an IC50 value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF‑κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394). |
| Molecular Weight | 348.4 |
| Molecular Formula | C19H24O6 |
| Canonical SMILES | CC1C2C(C3C4(C(CC(=O)C3(C1C(=O)O2)C)C(=CC(=O)C4O)C)C)O |
| Inchi | InChI=1S/C19H24O6/c1-7-5-10(20)16(23)18(3)9(7)6-11(21)19(4)12-8(2)14(25-17(12)24)13(22)15(18)19/h5,8-9,12-16,22-23H,6H2,1-4H3/t8-,9+,12-,13+,14-,15-,16-,18+,19+/m1/s1 |
| InChIKey | OGHYZHNTIINXEO-MGBQOKOWSA-N |
| Purity | 98% |
| Appearance | Cryst |
| Storage | 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light). |
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